Insertional and null mutants fail to convert to mold, do not accumulate significant biomass at 22☌, and are unable to suppress siderophore biosynthesis under iron-replete conditions. dermatitidis: phase transition from yeast to mold, cell growth at 22☌, and biosynthesis of siderophores under iron-replete conditions. We found that the GATA transcription factor SREB governs multiple fates in B. dermatitidis conidia and screened transformants for defects in morphogenesis. To identify genes that regulate this phase transition, we used Agrobacterium tumefaciens to mutagenize B. The ability to switch between these forms is essential for virulence in mammals and may enable these organisms to survive in the soil.
At 22☌, these fungi grow as mold that produce conidia or infectious particles, whereas at 37☌ they convert to budding yeast. Blastomyces dermatitidis belongs to a group of human pathogenic fungi that exhibit thermal dimorphism.
0 kommentar(er)
